We are proud members of the G.W. Hooper Foundation, located on the 15th floor of the HSW building (HSW 1521 and 1517), Parnassus Campus.
We are a new lab that just started our journey towards understanding the cell biology of host-pathogen interactions. We stand at the cross roads of mammalian cell biology and bacterial pathogenesis. Currently, we are using Legionella pneumophila, the causative agent of Legionnaires' disease, as a model to understand how bacteria survive the toxic environment of a host cell and create a replicative niche for themselves.
Broadly, we are interested in understanding how bacterial proteins subvert host vesicular transport processes and manipulate them to their own advantage. Understanding the mechanisms of host-pathogen interactions serves two main purposes. First, it provides an understanding of the mechanism of disease and thus leads to the development of better therapeutic approaches. Second, because bacteria disrupt host processes in multiple ways and often target key vesicular transport proteins, studying these interactions often lead to a deeper understanding of basic mammalian membrane transport processes.
With spectacular views of the bay area from our lab and really friendly neighbors, there is no shortage of inspiration to do great science!